Proxivir (300 mg) | ঔষধের দাম ও নির্দেশিকা

ব্যবহার

In combination with other antiretroviral agents, for the treatment of HIV-1 infection. Tenofovir Disoproxil is also indicated for the treatment of chronic hepatitis B in adults.

ফার্মাকোলজি

Mechanism of Action: Tenofovir inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5-triphosphate. Specifically, the drugs are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain.Pharmacokinetics: Tenofovir is a water soluble diester prodrug of the active ingredient Tenofovir. The oral bioavailability of Tenofovir is approximately 25%. Following oral administration of a single dose of Tenofovir 245 mg to HIV-1 infected subjects in the fasted state, maximum serum concentrations (Cmax) are achieved in 1.0 10.4 hrs. Cmax and AUC values are 0.30 0.09 ug/mL and 2.29 + 0.69 ug hr/mL, respectively. Protein binding Very low. <0.7% to human plasma proteins and <7.2% to serum proteins. Half life Approximately 17 hours. Tenofovir is eliminated by a combination of glomerular filtration and active tubular secretion.

সেবনবিধি

The size and frequency of the dosage must be adjusted to the needs of the individual patient. Tenofovir disoproxil 245 mg oral tablets should be administered once daily orally, without regard to food. Recommended Dose in Adults: For the treatment of HIV-1 or chronic hepatitis B: The dose is 245 mg Tenofovir tablet once daily taken orally, without regard to food. In the treatment of chronic hepatitis B, the optimal duration of treatment is unknown. Recommended Dose in Pediatric Patients (12 years of age and older and greater than or equal to 35 kg): For the treatment of HIV-1 in pediatric patients 12 years of age and older with body weight greater than or equal to 35 kg: The dose is one 245 mg Tenofovir tablet once daily taken orally, without regard to food.

পার্শ্বপ্রতিক্রিয়া

As with any medicine, side effects are possible with Tenofovir. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Headache, diarrhea, nausea, and weakness appear to be some of the most common side effects of Tenofovir. Other possible side effects include indigestion or heartburn, chest pain, and drowsiness. While most Tenofovir side effects are minor, there are a number of side effects that should be reported to your healthcare provider immediately, including high cholesterol or triglycerides, kidney problems, depression, and anxiety.

সতর্কতা

Lactic acidosis/severe hepatomegaly with steatosis: Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs, including Tenofovir, in combination with other antiretrovirals. A majority of these cases have been in women. Exacerbation of hepatitis after discontinuation of treatment discontinuation of anti-HBV therapy, including Tenofovir, may be associated with severe acute exacerbations of hepatitis. Patients infected with HBV who discontinue Tenofovir should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment. New onset or worsening renal impairment: Tenofovir is principally eliminated by the kidney. Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemial), has been reported with the use of Tenofovir.Coadministration with other products: Tenofovir should not be used in combination with the fixed-dose combination products which contains Tenofovir. Tenofovir should not be administered in combination with adefovir disoproxil.Patients Coinfected with HIV-1 and HBV: Due to the risk of development of HIV-1 resistance Tenofovir should only be used in HIV-1 and HBV coinfected patients as part of an appropriate antiretroviral combination regimen. Fat Redistribution In HIV-infected patients redistribution/accumulation of body fat including central obesity, dorsocervical fat enlargement buffalo hump), peripheral wasting, facial wasting, breast enlargement have been observed in patients receiving combination antiretroviral.Immune Reconstitution/Redistribution Syndrome: Immune reconstitution syndrome has been reported in HIV-infected patients treated with combination antiretroviral therapy, including Tenofovir.

গর্ভাবস্থায় ও স্তন্যদানকালে ব্যবহার

Pregnancy category B. No adequate and well-controlled studies in pregnant women. Tenofovir should be used during pregnancy only if clearly needed. The centers for disease control and prevention recommend that HIV-1-infected mothers not breastfeed their infants to avoid risking postnatal transmission of HIV-1. Pediatric Use: For the treatment of HIV-1 in pediatric patients 12 years of age and older with body weight greater than or equal to 35 kg: The dose is 245 mg Tenofovir tablet is once daily taken orally Geriatric Use: Clinical trials of Tenofovir did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for the elderly patient should be cautious, keeping in mind the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

সংরক্ষণ

Do not store above 25°C. Store in a cool and dry place, protected from light. Keep out of children’s reach.

বিকল্প ওষুধ

Proxivir 300 mg Tablet

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