Benozol BR (null) | ঔষধের দাম ও নির্দেশিকা

ব্যবহার

এটি একটি কার্বনিক অ্যানহাইড্রেজ ইনহিবিটর এবং একটি আলফা ২ অ্যাড্রেনার্জিক রিসেপ্টর অ্যাগোনিস্টের একটি নির্দিষ্ট সংমিশ্রণ যা ওপেন-এঙ্গেল গ্লুকোমা বা চোখের উচ্চ রক্তচাপের রোগীদের উচ্চতর ইন্ট্রাওকুলার চাপ কমানোর জন্য নির্দেশিত।

ফার্মাকোলজি

Brinzolamide (carbonic anhydrase inhibitor) and Brimonidine Tartrate (alpha 2 adrenergic receptor agonist). Each of these two components decreases elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. Brinzolamide inhibits carbonic anhydrase in the ciliary processes of the eye to decrease aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Brinzolamide has a peak ocular hypotensive effect occurring at 2 to 3 hours post-dosing.Fluorophotometric studies in animals and humans suggest that Brimonidine Tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. Brimonidine Tartrate has a peak ocular hypotensive effect occurring at two hours post-dosing. The result is a reduction in intraocular pressure (IOP).

সেবনবিধি

ব্যবহারের আগে ভালোভাবে ঝাঁকান। আক্রান্ত চোখে দিনে তিনবার এক ফোঁটা ব্যাবহার করুন। যদি একাধিক চক্ষু সংক্রান্ত ওষুধ ব্যবহার করা হয়, তবে ওষুধগুলি কমপক্ষে পাঁচ (৫) মিনিটের ব্যবধানে ব্যাবহার করা উচিত।

পার্শ্বপ্রতিক্রিয়া

The most frequently reported adverse reactions in patients treated with Benozol BR occurring in approximately 3 to 5% of patients were blurred vision, eye irritation, dysgeusia (bad taste), dry mouth, and eye allergy. Other adverse reactions that have been reported with the individual components during clinical trials are listed below. Brinzolamide 1%: The most frequently reported adverse reactions reported with Brinzolamide in 5 to 10% of patients were blurred vision and bitter, sour or unusual taste. Adverse reactions occurring in 1 to 5% of patients were blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus and rhinitis.Brimonidine Tartrate 0.2%: Adverse reactions occurring with Brimonidine Tartrate in approximately 10 to30% of the subjects, in descending order of incidence, included oral dryness, ocular hyperemia, burning and stinging, headache, blurring, foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions, and ocular pruritus.

সতর্কতা

Benozol BR contains Brinzolamide, a sulfonamide, and although administered topically is absorbed systemically. Therefore, the same types of adverse reactions that are attributable to sulfonamides may occur with topical administration of Benozol BR. Fatalities have occurred due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Brimonidine Tartrate also may potentiate syndromes associated with vascular insufficiency. Benozol BR should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, or thromboangitis obliterans. anemia, and other blood dyscrasias. Brinzolamide and its metabolite are excreted predominantly by the kidney, Benozol BR is not recommended in renal impairment patients. The preservative in Benozol BR, benzalkonium chloride, may be absorbed by soft contact lenses. Contact lenses should be removed during instillation of Benozol BR but may be reinserted 15 minutes after.

গর্ভাবস্থায় ও স্তন্যদানকালে ব্যবহার

Pregnancy Category C. Benozol BR should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Benozol BR are excreted in human milk following topical ocular administration. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Benozol BR, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

মাত্রাতিরিক্ত ব্যবহার

Although no human data are available, electrolyte imbalance, development of an acidotic state, and possible nervous system effects may occur following an oral overdose of Brinzolamide. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored. Very limited information exists on accidental ingestion of Brimonidine Tartrate in adults; the only adverse event reported to date has been hypotension. Symptoms of Brimonidine Tartrate overdose have been reported in neonates, infants, and children receiving Brimonidine Tartrate as part of medical treatment of congenital glaucoma or by accidental oral ingestion. Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained.

সংরক্ষণ

Store at room temperature & protect from light. Do not touch dropper tip to any surface. It is desirable that the contents should not be used more than one month after first opening of the bottle. Shake well before use & do not freeze.

বিকল্প ওষুধ

Benozol BR Ophthalmic Suspension

ডাক্তারের পরামর্শ